Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus.
Identifieur interne : 001154 ( Main/Exploration ); précédent : 001153; suivant : 001155Mapping the Specific Amino Acid Residues That Make Hamster DPP4 Functional as a Receptor for Middle East Respiratory Syndrome Coronavirus.
Auteurs : Neeltje Van Doremalen [États-Unis] ; Kerri L. Miazgowicz [États-Unis] ; Vincent J. MunsterSource :
- Journal of virology [ 1098-5514 ] ; 2016.
Descripteurs français
- KwdFr :
- Acides aminés (), Acides aminés (métabolisme), Animaux, Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (métabolisme), Coronavirus du syndrome respiratoire du Moyen-Orient (physiologie), Cricetinae, Dipeptidyl peptidase 4 (), Dipeptidyl peptidase 4 (métabolisme), Humains, Infections à coronavirus (virologie), Liaison aux protéines, Modèles animaux de maladie humaine, Modèles moléculaires, Pénétration virale, Récepteurs viraux (), Récepteurs viraux (métabolisme), Réplication virale.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- métabolisme : Acides aminés, Coronavirus du syndrome respiratoire du Moyen-Orient, Dipeptidyl peptidase 4, Récepteurs viraux.
- physiologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- virologie : Infections à coronavirus.
- Acides aminés, Animaux, Cricetinae, Dipeptidyl peptidase 4, Humains, Liaison aux protéines, Modèles animaux de maladie humaine, Modèles moléculaires, Pénétration virale, Récepteurs viraux, Réplication virale.
English descriptors
- KwdEn :
- Amino Acids (chemistry), Amino Acids (metabolism), Animals, Coronavirus Infections (virology), Cricetinae, Dipeptidyl Peptidase 4 (chemistry), Dipeptidyl Peptidase 4 (metabolism), Disease Models, Animal, Humans, Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (metabolism), Middle East Respiratory Syndrome Coronavirus (physiology), Models, Molecular, Protein Binding, Receptors, Virus (chemistry), Receptors, Virus (metabolism), Virus Internalization, Virus Replication.
- MESH :
- chemical , chemistry : Amino Acids, Dipeptidyl Peptidase 4, Receptors, Virus.
- chemical , metabolism : Amino Acids, Dipeptidyl Peptidase 4, Receptors, Virus.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- metabolism : Middle East Respiratory Syndrome Coronavirus.
- physiology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections.
- Animals, Cricetinae, Disease Models, Animal, Humans, Models, Molecular, Protein Binding, Virus Internalization, Virus Replication.
Abstract
The novel emerging coronavirus Middle East respiratory syndrome coronavirus (MERS-CoV) binds to its receptor, dipeptidyl peptidase 4 (DPP4), via 14 interacting amino acids. We previously showed that if the five interacting amino acids which differ between hamster and human DPP4 are changed to the residues found in human DPP4, hamster DPP4 does act as a receptor. Here, we show that the functionality of hamster DPP4 as a receptor is severely decreased if less than 4 out of 5 amino acids are changed.
DOI: 10.1128/JVI.03267-15
PubMed: 27030263
Affiliations:
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Le document en format XML
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We previously showed that if the five interacting amino acids which differ between hamster and human DPP4 are changed to the residues found in human DPP4, hamster DPP4 does act as a receptor. Here, we show that the functionality of hamster DPP4 as a receptor is severely decreased if less than 4 out of 5 amino acids are changed.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Montana</li></region></list><tree><noCountry><name sortKey="Munster, Vincent J" sort="Munster, Vincent J" uniqKey="Munster V" first="Vincent J" last="Munster">Vincent J. Munster</name></noCountry><country name="États-Unis"><region name="Montana"><name sortKey="Van Doremalen, Neeltje" sort="Van Doremalen, Neeltje" uniqKey="Van Doremalen N" first="Neeltje" last="Van Doremalen">Neeltje Van Doremalen</name></region><name sortKey="Miazgowicz, Kerri L" sort="Miazgowicz, Kerri L" uniqKey="Miazgowicz K" first="Kerri L" last="Miazgowicz">Kerri L. 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